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Apexbio Technology LLC RI-2 1417162-36-7 10mg
Supplier: Apexbio Technology LLC B588110
RI-2 (CAS 1417162-36-7) is a reversible small molecule inhibitor of RAD51 a conserved protein essential for homologous recombination (HR)-mediated DNA repair RAD51 is frequently overexpressed in cancer cells making it a relevant target for oncology research RI-2 inhibits RAD51 activity with an IC50 of 44 17 M impairing RAD51-mediated DNA binding in vitro Unlike some related compounds RI-2 does not react with glutathione after 24 hours of incubation indicating it lacks irreversible Michael acceptor reactivity RI-2 is under preclinical investigation as a research tool for studying HR pathways and potential strategies to sensitize cancer cells to DNA-damaging therapies
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