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AdipoGen Ribavirin (250 mg)
Supplier: AdipoGen AGCR13719M250
Chemical. CAS: 36791-04-5. Formula: C8H12N4O5. MW: 244.2. Ribavirin is a guanosine analog with broad-spectrum antiviral properties against DNA and RNA viruses, including coronavirus SARS, respiratory syncytial virus, several hemorrhagic fever viruses, hepatitis C (HCV) and influenza. It is also tested for SARS-CoV-2. It acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases. Ribavirin shows anticancer properties. The principal target in several cancers is the oncogenic eukaryotic translation initiation factor 4E (eIF4E), modulated via direct binding and competitive inhibition. Ribavirin has been shown to bind eIF4E at the functional site used to bind the m7G cap of mRNA transcripts in vitro. It competes with target mRNAs for binding, subsequent translocation to the cytoplasm and ultimately translation. Other studies also demonstrate modulation of several other key pathways including ERK, EZH2 and IMPDH.
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