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Medchemexpress LLC Rimantadine hydrochloride | 1501-84-4 | 98.0% | 50 G
Supplier: Medchemexpress LLC HYB0338A50G
Rimantadine hydrochloride is an orally active inhibitor for M2 protein. It blocks hydrogen ion channel activity, preventing virus entry and replication, and exhibiting broad-spectrum antiviral activity. It has shown efficacy in inhibiting RNA levels of hepatitis A virus (HAV) in Huh7 and IHH cells and promoting autophagy. In vivo studies also indicate anti-infectious activity in H3N2-infected mouse models.
- Blocks hydrogen ion channel activity
- Prevents virus entry and replication
- Exhibits broad-spectrum antiviral activity
- Inhibits RNA levels of hepatitis A virus (HAV) in Huh7 and IHH cells
- Increases expression of autophagy marker LC3
- Inhibits mTOR phosphorylation
- Increases lysosome number
- Promotes autophagy in HAV-infected Huh7 cells
- Exhibits anti-infectious activity in H3N2-infected mouse models
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