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Apexbio Technology LLC Ro 31-8220 Mesylate(Synonyms: Ro 31-8220 Methanesulfonate, Bisindolylmaleimide IX mesylate, Ro-318220 Mesylate), 50mg, CAS: 138489-18-6.
Supplier: Apexbio Technology LLC B219250
Ro 31-8220 Mesylate (CAS 138489-18-6) is a selective small molecule inhibitor of protein kinase C (PKC) targeting multiple PKC isoforms ( I II and ) with IC50 values ranging from 5 to 27 nM PKC constitutes a family of calcium- and phospholipid-dependent serine/threonine kinases implicated in signaling pathways associated with growth factor responses and malignant transformation Ro 31-8220 modulates downstream targets inhibiting MKP-1 and c-Fos expression while inducing c-Jun and activating Jun N-terminal kinase (JNK) in a PKC-dependent manner It suppresses mitogen-induced IL-2 production and T-cell proliferation suggesting utility in immunological research and affects glucose metabolism via JNK and glycogen synthase activation relevant to metabolic studies
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