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Medchemexpress LLC Ro 61-8048 | 199666-03-0 | 99.8% | 421.45 | 100 MG
Supplier: Medchemexpress LLC 100MGHY12347
Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, demonstrating an IC50 of 37 nM. This compound significantly increases extracellular kynurenic acid concentrations and has shown potential in reducing QUIN neo-formation and the severity of dystonia in experimental models.
- Orally active and selective kynurenine 3-hydroxylase inhibitor
- Increases extracellular kynurenic acid concentrations
- Reduces QUIN neo-formation
- Inhibits cerebral enzyme activity in vivo
- Reduces severity of dystonia in dtsz hamsters
- Appearance is a solid, off-white to light yellow in color
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