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Medchemexpress LLC Ro4987655 | 874101-00-5 | 99.0% | 565.28 | 25 MG
Supplier: Medchemexpress LLC 25MGHY14719
Ro4987655 is an orally active and highly selective MEK inhibitor with an IC50 of 5.2 nM for inhibition of MEK1/MEK2. It potently inhibits the mitogen-activated protein kinase signaling pathway activation and tumor cell growth, and inhibits proliferation of NCI-H2122 cells in a dose-dependent manner. This compound appears as a solid, white to off-white in color.
- Highly selective MEK1/MEK2 inhibitor
- Potently inhibits MAPK signaling pathway and tumor cell growth
- Inhibits proliferation of NCI-H2122 cells
- Achieves complete tumor regression in xenograft models with single-agent oral administration
- Rapidly absorbed with dose-proportional exposures
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