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Medchemexpress LLC RO6806051 | 1433901-75-7 | 99.84% | 390.87 | 50 MG
Supplier: Medchemexpress LLC HY16170250MG
RO6806051 is a selective FABP4 and FABP5 inhibitor for research of inflammation-related diseases. It is a potent dual inhibitor of purified human hFABP4 and hFABP5, showing approximately 209-fold selectivity for hFABP4 over hFABP3 and about 27-fold selectivity for hFABP5 over hFABP3.
- Selective FABP4 and FABP5 inhibitor
- Human FABP4 Ki values of 0.011 μM and 0.23 μM
- Human FABP5 Ki values of 0.086 μM and 1.17 μM
- Suitable for research of inflammation-related diseases
- Exhibits favorable physicochemical properties
- Low liver microsomal clearance in human and mouse
- Weak to no inhibition of major cytochrome P450 enzymes
- Shows significant cytotoxicity against differentiated THP-1 macrophages at concentrations of 20 μM and above
- Moderately inhibits MCP-1 secretion in LPS-stimulated THP-1 macrophages
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