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Medchemexpress LLC Roniciclib | 1223498-69-8 | 98.0% | 430.44 | 25 MG
Supplier: Medchemexpress LLC 25MGHY13914
Roniciclib is an orally bioavailable pan-cyclin dependent kinase (CDK) inhibitor. It has IC50s of 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7, and CDK9.
- Inhibits the kinase activity of cell-cycle CDKs (CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D)
- Inhibits transcriptional CDKs (CDK9/cyclin T1 and CDK7/cyclin H/MAT1)
- Potently inhibits the proliferation of various human and murine tumor cell lines
- Strongly inhibits tumor growth in a dose-dependent manner
- Low blood clearance rates in mouse, rat, and dog
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