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Medchemexpress LLC Rosuvastatin (calcium) | 147098-20-2 | 99.8% | 500.57 | 100 MG
Supplier: Medchemexpress LLC HY17504100MG
Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM, that potently blocks hERG current with an IC50 of 195 nM. It reduces the expression of mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. This compound effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels and is for research use only.
- Competitive HMG-CoA reductase (HMGCR) inhibitor
- Potently blocks hERG current
- Reduces expression of mature hERG
- Reduces interaction of heat shock protein 70 (Hsp70) with the hERG protein
- Effectively lowers low-density lipoprotein (LDL) cholesterol
- Effectively lowers triglycerides
- Effectively lowers C-reactive protein levels
- Prolongs QTc in conscious and unrestrained guinea pigs
- Reduces very low-density lipoproteins (VLDL) in diabetes mellitus rats
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