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Medchemexpress LLC RTI-13951-33 hydrochloride | 98.6% | 532.50 | 100 MG
Supplier: Medchemexpress LLC HY112612A100MG
RTI-13951-33 hydrochloride is a potent, selective, and brain-penetrant GPR88 agonist with an EC50 of 25 nM in a GPR88 cAMP functional assay. This compound reduces alcohol reinforcement and intake behaviors in rats.
- Potent, selective, and brain-penetrant GPR88 agonist.
- Displays an EC50 of 25 nM in GPR88 cAMP functional assay.
- Elevates [35S]-GTPγS binding (EC50, 535 nM) in mouse striatal membranes, but not in membranes from GPR88 knockout mice.
- Exhibits weak affinities at kappa opioid receptor (KOR; Ki, 2.29 μM) and vesicular monoamine transporter (VMAT; Ki, 4.23 μM).
- Shows sufficient brain penetration with a half-life (t1/2) of 48 minutes in rat plasma and 87 minutes in rat brain.
- Dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration.
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