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Selleck Chemical LLC Ruxolitinib S1378-1g
Supplier: Selleck Chemical LLC S13781G
Ruxolitinib is the first potent selective JAK1/2 inhibitor to enter the clinic with IC50 of 3 3 nM/2 8 nM in cell-free assays 130-fold selectivity for JAK1/2 versus JAK3 Ruxolitinib kills tumor cells through toxic mitophagy Ruxolitinib induces autophagy and enhances apoptosis
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