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Apexbio Technology LLC Ruxolitinib phosphate 1092939-17-7 100mg
Supplier: Apexbio Technology LLC A3781100
Ruxolitinib phosphate (CAS 1092939-17-7) is an orally available small molecule inhibitor selective for Janus-associated kinases (JAKs) particularly potent against JAK1 and JAK2 with IC50 values of approximately 3 nM and 5 nM respectively It displays relatively lower inhibitory activity toward JAK3 (IC50 332 nM) By blocking JAK-mediated signal transduction Ruxolitinib phosphate disrupts downstream cytokine signaling pathways involved in inflammatory and proliferative responses This compound is widely utilized in biomedical research focusing on inflammatory disorders particularly rheumatoid arthritis
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