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Medchemexpress LLC Ruxolitinib phosphate (synonyms: INCB018424 phosphate) | 1092939-17-7 | MFCD29938883 | 99.97% | C17H18N6.H3PO4 | 500 MG
Supplier: Medchemexpress LLC HY50858500MG
Ruxolitinib phosphate, also known as INCB018424 phosphate, is a potent inhibitor of JAK1 and JAK2, with IC50s of 3.3 nM and 2.8 nM, respectively. It exhibits over 130-fold selectivity for JAK3, making it a highly selective compound for research applications. This inhibitor also effectively suppresses JAK2V617F-mediated signaling and proliferation, and inhibits HEL cell growth at an EC50 of 186 nM.
- Potent JAK1/2 inhibitor
- Highly selective over JAK3
- Inhibits JAK2V617F-mediated signaling
- Suppresses HEL cell growth
- Increases apoptosis in Ba/F3-EpoR-JAK2V617F cell systems
- Inhibits hematopoietic progenitor cell proliferation
- Reduces tumor burden in vivo without anemia or lymphopenia
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