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Medchemexpress LLC Ruxolitinib (S enantiomer) | 941685-37-6 | 99.6% | C17H18N6 | 200 MG
Supplier: Medchemexpress LLC HY50856A200MG
Ruxolitinib (S enantiomer), also known as S-Ruxolitinib, is the S-enantiomer of Ruxolitinib and acts as an orally active, potent JAK inhibitor.
- In vitro: suppresses IFNβ-induced expression of ISG, IFIT, and IFITM in human small airway epithelial cells (SAECs) at a concentration of 10 μM for 12 hours.
- In vivo: reduces hematopoietic cell expansion in myeloproliferative neoplasms (MPNs) in female wild-type C57BL/6J or Nes-gfp27 mice when administered via oral gavage at 30 mg/kg, twice per day for 8 weeks.
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