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Medchemexpress LLC S 18986 | 175340-20-2 | 99.9% | 224.28 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY1093610MM/1ML

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S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors. It exhibits cognitive enhancing properties in rodents, activating the release of noradrenaline and acetylcholine in the rat hippocampus and improving memory in object-recognition tests.

  • Selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors.
  • Shows cognitive enhancing properties in rodents.
  • Activates the release of noradrenaline and acetylcholine in rat hippocampus.
  • Enhances rat memory in object-recognition tests.
  • Exhibits robust memory-enhancing effects in middle-aged animals compared with aged ones.
  • Shows antiamnesic properties in middle-aged rodents in spatial memory models.
  • Significantly increases both the induction and maintenance of 4 and 20 bursts tetanus-evoked potentiation at dosages of 5-50 mg/kg (i.p.).

Catalog No. 50-003-45934


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