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Medchemexpress LLC β-S-ARCA (triammonium) | 1093268-63-3 | 99.48% | C22H40N13O17P3S | 50 MG
Supplier: Medchemexpress LLC HY145969A50MG
β-S-ARCA (triammonium) is an mRNA 7-methylguanosine (m7G) cap analog designed to bind to eIF4E via a phosphorothioate (PS) moiety. This compound prevents decapping by Dcp2, thereby extending mRNA half-life, enhancing cap-dependent translation, and increasing protein expression. It has been applied in research for experimental mRNA-based anticancer vaccines. The compound exists as a pair of diastereomers, exhibiting distinct binding affinities to purified eIF4E.
- Functions as an mRNA 7-methylguanosine (m7G) cap analog
- Contains a phosphorothioate (PS) moiety for eIF4E binding
- Prevents mRNA decapping by Dcp2
- Increases mRNA half-life
- Enhances cap-dependent translation
- Boosts protein expression in cells
- Used in research for mRNA-based anticancer vaccines
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