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Medchemexpress LLC (S,R)-GSK321 | 1816272-18-0 | 98.6% | 50 MG
Supplier: Medchemexpress LLC HY128888B50MG
(S,R)-GSK321 is the (S,R)-enantiomer of GSK321, a potent and selective mutant IDH1 inhibitor with strong activity against various mutant IDH1 forms and high selectivity over IDH2. It induces a decrease in intracellular 2-HG, helps abrogate myeloid differentiation block, and promotes granulocytic differentiation in leukemic blasts and more immature stem-like cells. This compound is intended for research use in studies related to acute myeloid leukemia (AML) and other cancers, and is not sold to patients.
- Potent and selective mutant IDH1 inhibitor
- High selectivity over IDH2
- Induces a decrease in intracellular 2-HG
- Abrogates myeloid differentiation block
- Induces granulocytic differentiation
- Suitable for research on acute myeloid leukemia (AML) and other cancers
- Molecular weight: 501.55
- Chemical formula: C28H28FN5O3
- Appearance: white to off-white solid
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