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Apexbio Technology LLC S-Ruxolitinib (INCB018424) 941685-37-6 1mg
Supplier: Apexbio Technology LLC A41491
S-Ruxolitinib (INCB018424 CAS 941685-37-6) is the chiral form of ruxolitinib acting as a selective inhibitor of Janus kinases JAK1 and JAK2 By competitively blocking the ATP-binding site within the kinase domain S-Ruxolitinib disrupts JAK-STAT pathway signaling which is essential for the function of various cytokine and growth factor receptors involved in hematopoiesis and immune regulation In studies using JAK2V617F-positive Ba/F3 cells ruxolitinib has been shown to reduce cellular proliferation This compound is widely utilized in research to investigate JAK-mediated signal transduction and to explore therapeutic strategies targeting aberrant JAK activity in hematologic disorders
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