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Medchemexpress LLC (S)-TNG260 | 2935964-93-3 | C20H18FN3O2S | 1 ML
Supplier: Medchemexpress LLC HY153358A10MM/1ML
(S)-TNG260 is an isomer of TNG260, which functions as a CoREST selective deacetylase (CoreDAC) inhibitor. It demonstrates significant selectivity, inhibiting HDAC1 with 10-fold preference over HDAC3. This compound is known to induce HDAC1 inhibition, effectively reversing anti-PD1 resistance associated with STK11 deletion. Additionally, it reduces intratumoral neutrophil infiltration and exhibits immune-mediated cell killing.
- CoREST selective deacetylase (CoreDAC) inhibitor
- Inhibits HDAC1 with 10-fold selectivity over HDAC3
- Reverses anti-PD1 resistance driven by STK11 deletion
- Reduces intratumoral infiltration of neutrophils
- Exhibits immune-mediated cell killing
- Purity of 98.84%
- Molecular weight is 383.44
- Appears as an off-white to light yellow solid
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