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Medchemexpress LLC S-Trityl-L-cysteine | 2799-07-7 | 99.0% | 363.47 | 50 MG
Supplier: Medchemexpress LLC HYW01110250MG
S-Trityl-L-cysteine is a selective and allosteric kinesin Eg5 inhibitor, demonstrating antitumor activities. It inhibits basal ATPase activity with an IC50 of 1 μM and microtubule-activated ATPase activity with an IC50 of 140 nM. The compound binds to a unique pocket within the Eg5 motor domain.
- Mediates cell apoptosis and cell cycle arrest in a dose-dependent manner.
- Triggers activation of mitogen-activated protein kinase and nuclear factor κB signaling pathways.
- Induces mitotic arrest in HeLa cells with characteristic monoastral spindles.
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