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Medchemexpress LLC S-Trityl-L-cysteine | 2799-07-7 | MFCD00009941 | 99.0% | 363.47 | 500 MG
SDP

Supplier:  Medchemexpress LLC HYW011102500MG

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S-Trityl-L-cysteine is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. It also possesses antitumor activities.

  • Selective and allosteric kinesin Eg5 inhibitor.
  • Exhibits antitumor activities.
  • Binds to a unique pocket in the Eg5 motor domain.
  • Mediates cell apoptosis and cell cycle arrest in a dose-dependent manner.
  • Triggers apoptosis and cell cycle arrest via activation of the mitogen-activated protein kinase and nuclear factor kB signaling pathways.
  • Induces mitotic arrest in HeLa cells with characteristic monoastral spindles.

Catalog No. 50-004-52811


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