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Apexbio Technology LLC S0859 1019331-10-2 10mg
Supplier: Apexbio Technology LLC A378310
S0859 (CAS 1019331-10-2) is an N-cyanosulphonamide small molecule that reversibly inhibits Na -coupled HCO3 transporters (NBCs) central regulators of intracellular pH via bicarbonate ion flux S0859 displays a Ki of 1 7 M in suppressing NBC-mediated intracellular pH recovery with full inhibition observed near 30 M Disruption of NBC activity has been implicated in various pathological conditions including the up-regulation of NBCn1 in ErbB2-dependent breast cancer models and associations with hypertension In cellular assays S0859 treatment increased caspase-3 activation and apoptotic cell numbers This compound is valuable for studies investigating NBC function in cardiac and other physiological or disease contexts
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