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Cayman Chemical S1RAhydrochlorIde 10mg
Supplier: Cayman Chemical 3272910 MG
A σ1 receptor antagonist (Ki = 17 nM); selective for σ1 receptors over σ2 receptors (Ki = 9,300 nM), as well as a panel of 170 additional receptors at 1 µM; reduces capsaicin-induced mechanical allodynia, formalin-induced licking and biting behavior, and partial sciatic nerve-ligation induced thermal hyperalgesia in mice (ED50s = 26.3, 43.7, and 18.8 mg/kg, respectively); enhances fentanyl- or loperamide-induced analgesia without affecting gastrointestinal transit in mice
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