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Apexbio Technology LLC S63845 1799633-27-4 25mg
Supplier: Apexbio Technology LLC A873725
S63845 (CAS 1799633-27-4) is a small molecule inhibitor targeting myeloid cell leukemia 1 (MCL1) an anti-apoptotic member of the BCL-2 protein family MCL1 is frequently overexpressed in various cancers enabling cell survival through inhibition of apoptosis mediated by mitochondrial pathways S63845 binds human MCL1 with high affinity (KD 0 19 nM) blocking MCL1 interaction with pro-apoptotic proteins BAK and BAX thereby activating mitochondrial apoptosis characterized by cytochrome c release phosphatidylserine externalization and PARP cleavage In preclinical studies using MCL1-dependent multiple myeloma xenograft mouse models (H929 AMO1) intravenous administration of S63845 demonstrated dose-dependent tumor growth inhibition supporting its utility in cancer apoptosis research
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