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Medchemexpress LLC S65487 sulfate | 2416937-01-2 | 99.35% | 815.33 | 1 ML
Supplier: Medchemexpress LLC HY138697A10MM/1ML
S65487 sulfate is a potent and selective Bcl-2 inhibitor, functioning as a proagent of S55746. It induces apoptosis and exhibits anticancer activities by binding to the BH3 hydrophobic groove of Bcl-2.
- Active against Bcl-2 mutations like G101V and D103Y
- Induces apoptosis and inhibits cell proliferation in hematological cancer cell lines
- Shows poor affinity with Mcl-1, Bfl-1, and Bcl-XL
- Induces complete regression in Bcl-2-dependent RS4;11 tumors in vivo after a single intravenous administration
- Demonstrates strong and persistent tumor regression in xenograft models of lymphoid malignancies when combined with a Mcl-1-specific inhibitor
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