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Apexbio Technology LLC Sabutoclax 1228108-65-3 5mg
Supplier: Apexbio Technology LLC A41995
Sabutoclax (CAS 1228108-65-3) is a small-molecule inhibitor targeting multiple anti-apoptotic proteins of the Bcl-2 family including Bcl-xL Bcl-2 Mcl-1 and Bfl-1 with IC50 values of 0 31 M 0 32 M 0 20 M and 0 62 M respectively Derived from apogossypolone sabutoclax exhibits high affinity for Bcl-xL (Kd 0 11 M) and enhanced membrane permeability relative to related analogs In cellular studies sabutoclax suppresses PC3 cell proliferation (EC50 0 13 M) and induces apoptosis in human BP3 cells (IC50 0 049 M) In M2182 xenograft mouse models sabutoclax significantly reduces tumor volume with nearly complete inhibition of tumor growth at a dose of 5 mg/kg Sabutoclax is utilized to investigate Bcl-2 family inhibition in cancer research
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