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Medchemexpress LLC Sacubitril (AHU-377) | 149709-62-6 | 99.9% | 411.49 | 100 MG
Supplier: Medchemexpress LLC 100MGHY15407
Sacubitril (AHU-377) is a potent, orally active neprilysin (NEP) inhibitor with an IC50 of 5 nM. It is a component of the heart failure medicine LCZ696 and is used for the research of heart failure, hypertension, and COVID-19. It enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects.
- Potent and orally active neprilysin (NEP) inhibitor
- IC50 of 5 nM for NEP
- Component of heart failure medicine LCZ696
- Used for research on heart failure, hypertension, and COVID-19
- Enhances natriuretic peptide (NP) system tone
- Exerts significant antihypertensive effects
- Converted to active metabolite LBQ657
- Active metabolite inhibits cardiac myocyte hypertrophy
- Potentiates ANF-induced urinary sodium excretion
- Augments ANP-evoked plasma cGMP levels
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