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Medchemexpress LLC SAG dihydrochloride | 2702366-44-5 | 98.2% | 100 MG
Supplier: Medchemexpress LLC HY12848C100MG
SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist with an EC50 of 3 nM and a Kd of 59 nM. It activates the Hedgehog signaling pathway and counteracts Cyclopamine inhibition of Smo, making it suitable for various research applications.
- Potent Smoothened (Smo) receptor agonist
- Activates the Hedgehog signaling pathway
- Counteracts Cyclopamine inhibition of Smo
- Induces firefly luciferase expression in Shh-LIGHT2 cells
- Competes for binding of BODIPY-cyclopamine to Smo-expressing Cos-1 cells
- Increases SMO mRNA and protein expression in MDAMB231 cells
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