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Medchemexpress LLC SAH-SOS1A TFA | 2896737-31-6 | 96.6% | 2301.55 | 10 MG
SDP

Supplier:  Medchemexpress LLC HYP2265A10MG

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SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. It binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity (EC50=106-175 nM). This compound directly and independently blocks nucleotide association, impairs KRAS-driven cancer cell viability, and exerts its effects by on-mechanism blockade of the ERK-MAPK phosphosignaling cascade downstream of KRAS.

  • Peptide-based SOS1/KRAS protein interaction inhibitor
  • Binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, Q61H) with nanomolar affinity
  • Directly and independently blocks nucleotide association
  • Impairs cancer cell viability
  • Inhibits MEK1/2, ERK1/2, and AKT phosphorylation

Catalog No. 50-004-23882


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