IBL America sAPPα (2B3) Anti-Human Mouse IgG MoAb, 100 µg

Supplier:  IBL America 11088

Amyloid precursor protein (APP) is precursor protein of Amyloid β which is major constituent of senile plaque in Alzheimer's disease. It is known that there are three major isoforms, APP695, APP751 and APP770, and are generated from alternative splicing of common precursor mRNA. Processing of APP occurs by two major pathways, non-amyloidogenic pathway and amyloidogenic pathway. The non-amyloidogenic pathway is mediated by α and γ-secretases and gives rise to a large fragment known as soluble APPα (sAPPα) and a small 3 kDa peptide known as p3. On the other hand, the Amyloidogenic pathway is mediated by β- and γ-secretases and yields soluble APPβ (sAPPβ) and Amyloid β. The physiologic function of APP itself is not clear, however, it is supposed that the function of APP in neuron system is different from that in other organ. Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by beta- and gamma-secretases.

Catalog No. NC3734721