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Apexbio Technology LLC Saquinavir mesylate 149845-06-7 200mg
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Supplier:  Apexbio Technology LLC A3791200

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Saquinavir mesylate is a reversible inhibitor of HIV protease a retroviral aspartic protease required for viral maturation and replication It targets the active site of HIV-1 and HIV-2 proteases preventing enzymatic cleavage of polyprotein precursors thereby suppressing formation of mature viral particles Saquinavir inhibits HIV-1 protease with a reported Ki value of approximately 0 12 nM In cultured human neuronal cells it also reduces -amyloid (A 40) levels and inhibits -secretase (BACE1) activity at 50 M concentration it reduces neuronal A production by approximately 90% Saquinavir is commonly employed in HIV/AIDS research and has potential in Alzheimer s disease models for studying the modulation of amyloid peptide synthesis pathways

Catalog No. 50-000-63833


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