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Apexbio Technology LLC SAR131675 1433953-83-3 5mg
Supplier: Apexbio Technology LLC B23015
SAR131675 (CAS 1433953-83-3) is a selective ATP-competitive inhibitor of vascular endothelial growth factor receptor 3 (VEGFR-3) exhibiting an IC50 of 20 23 nM for VEGFR-3 kinase inhibition and a Ki of 12 nM In cellular assays SAR131675 effectively blocks VEGFR-3 autophosphorylation in HEK cells (IC50 30 50 nM) and demonstrates minimal inhibition of VEGFR-1 ( 3 M) and VEGFR-2 (235 nM) The compound does not inhibit a broad panel of kinases non-kinase receptors or ion channels SAR131675 suppresses VEGFC/VEGFD-induced lymphocyte survival (IC50 14 17 nM) and impedes VEGFA/VEGFC-stimulated migration in endothelial cells In vivo it reduces lymphangiogenesis angiogenesis and tumor growth in mouse models This molecule is suited for studies on VEGFR-3 mediated signaling lymphangiogenesis and cancer metastasis
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