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Apexbio Technology LLC SAR405 1523406-39-4 10mg
Supplier: Apexbio Technology LLC A888310
SAR405 (CAS 1523406-39-4) is a selective ATP-competitive inhibitor of class III phosphoinositide 3-kinase Vps34 Vps34 regulates autophagy and vesicle trafficking through phosphatidylinositol 3-phosphate (PtdIns3P) production SAR405 inhibits human recombinant Vps34 kinase activity with an IC50 of approximately 1 nM thereby reducing levels of PtdIns3P without affecting related kinases such as class I/II PI3Ks or mTOR at concentrations up to 10 M In cellular assays SAR405 treatment impairs late endosome lysosome maturation blocks autophagic flux and disrupts cathepsin D processing SAR405 serves as a pharmacological tool for studying Vps34-mediated vesicle transport pathways and autophagy regulation
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