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Apexbio Technology LLC SAR407899 923359-38-0 2mg
Supplier: Apexbio Technology LLC B49102
SAR407899 (CAS 923359-38-0) is an ATP-competitive inhibitor that selectively targets the ROCK-2 isoform of Rho-associated protein kinases It demonstrates an IC50 of 135 nM for ROCK-2 and binds with Ki values of 36 nM and 41 nM for human and rat ROCK-2 respectively Through selective modulation of the ROCK signaling pathway SAR407899 has been shown to sustain inhibition of migration complex formation in cellular models This compound is thus suited for investigating cell migration cytoskeletal reorganization and the functional role of ROCK signaling in biomedical research
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