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Cayman Chemical SARSCoV2 SpIke GlycoproteIn

Supplier: Cayman Chemical 30590100 UG

A thymidylate synthase inhibitor (Ki 11 nM) inhibits cell growth in a panel of human and murine cancer cell lines (IC50s 0 39-6 6 M) inhibits the growth of L1210 cells an effect that is decreased by greater than 50-fold by the addition of exogenous thymidine induces cell cycle arrest at the S phase in L1210 cells at 0 7 and 3 5 M increases life span in a thymidine kinase-deficient L5178Y/TK- murine lymphoma model at 25-200 mg/kg
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