Cayman Chemical Saururaceae SauchInon 10mg

Supplier:  Cayman Chemical 1957710 MG

A lignan with diverse biological activities; inhibits LPS-induced expression of the genes encoding iNOS, TNF-α, and COX-2 (IC50s = ≤10 µM for all), as well as LPS-induced activation of NF-κB and nuclear translocation of NF-κB p65 in RAW 264.7 cells; reduces hydrogen peroxide-induced increases in Hsp70 levels and cell death in C2C12 mouse skeletal muscle myoblasts; reduces hepatic formation of TBARS, plasma levels of ALT, and hepatocyte cell death in a mouse model of iron overload-induced liver injury at 10 and 30 mg/kg; reduces infarct size and heart levels of phosphorylated p38 MAPK and JNK in a rat model of myocardial ischemia-reperfusion injury

Catalog No. 50-298-1600