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Apexbio Technology LLC SB-222200 174635-69-9 50mg
Supplier: Apexbio Technology LLC A379550
SB-222200 (CAS 174635-69-9) is a potent and selective nonpeptide antagonist of the neurokinin-3 (NK-3) receptor a G protein-coupled receptor involved in mediating tachykinin signaling via phospholipase C activation and downstream inositol phosphate pathways In vitro SB-222200 exhibits high affinity for human NK-3 receptors in CHO cells (Ki 4 4 nM) and effectively antagonizes neurokinin B-induced calcium mobilization in HEK293 cells (IC50 18 4 nM) In murine models SB-222200 dose-dependently suppresses NK-3 agonist-evoked behavioral responses with efficacy correlated to its brain concentration The compound is valuable for investigating NK-3 receptor function and its role in dopaminergic and behavioral regulation
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