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Medchemexpress LLC SB 271046 Hydrochloride | 209481-24-3 | 99.9% | C20H23Cl2N3O3S2 | 1 ML
Supplier: Medchemexpress LLC HY14336A10MM/1ML
SB 271046 Hydrochloride is a potent, selective, orally active, and BBB-permeable 5-HT6 receptor antagonist. It exhibits pKi values of 9.02, 8.55, and 8.81 for rat, pig, and human receptors, respectively. The compound is over 200-fold selective for the 5-HT6 receptor compared to 55 other receptors, binding sites, and ion channels, and demonstrates anticonvulsant activity with an EC50 of 0.16 μM.
- Potent, selective, orally active, and BBB-permeable 5-HT6 receptor antagonist
- Over 200-fold selectivity for the 5-HT6 receptor
- Exhibits anticonvulsant activity
- Competitively antagonizes 5-HT-induced stimulation of adenylyl cyclase activity
- Increases seizure threshold
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