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Apexbio Technology LLC SB 290157 (trifluoroacetate salt) 1140525-25-2 25mg
Supplier: Apexbio Technology LLC C356325
SB 290157 (trifluoroacetate salt CAS 1140525-25-2) is a small-molecule antagonist of the complement component 3a receptor (C3aR) a G protein-coupled receptor activated by the inflammatory mediator C3a In cellular assays SB 290157 competitively inhibits C3a binding to human C3aR with an IC50 of 200 nM and blocks C3a-induced receptor internalization and calcium mobilization in RBL-2H3 cells and human neutrophils The compound displays selectivity for C3aR showing no antagonism toward C5aR or other chemotactic GPCRs In animal studies SB 290157 reduces neutrophil recruitment and inflammatory responses supporting its utility in studying C3aR-mediated immune mechanisms
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