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Medchemexpress LLC SB 415286 | 264218-23-7 | C16H10ClN3O5 | 100 MG
Supplier: Medchemexpress LLC HY15438100MG
SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α and GSK-3β, with an IC50 of 77.5 nM and a Ki of 30.75 nM. This compound stimulates glycogen synthesis and induces transcription of a β-catenin-LEF/TCF regulated reporter gene. It is supplied as a light yellow to yellow solid.
- Potent and selective cell permeable GSK-3α and GSK-3β inhibitor.
- Stimulates glycogen synthesis in Chang human liver cell line.
- Induces transcription of a β-catenin-LEF/TCF regulated reporter gene in HEK293 cells.
- Attenuates B65 cell loss and ROS production mediated by hydrogen peroxide.
- Suppresses immunoprecipitated GSK3 activity by 97% at 50 μM.
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