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Medchemexpress LLC SB-612111 hydrochloride | 371980-94-8 | 99.6% | 454.86 | 25 MG
Supplier: Medchemexpress LLC 25MGHY18618A
SB-612111 hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist. It demonstrates high affinity for hORL-1 and selectivity for μ-, κ- and δ-receptors. This compound effectively antagonizes the pronociceptive action of Nociceptin in acute pain models.
- Potent opiate receptor-like orphan receptor (ORL-1) antagonist
- High affinity for hORL-1 (Ki=0.33 nM)
- Exhibits selectivity for μ-, κ- and δ-receptors
- Antagonizes pronociceptive action of Nociceptin
- Had antihyperalgesic effects on carrageenan-induced rat paw
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