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Apexbio Technology LLC SB505124 694433-59-5 10mg
Supplier: Apexbio Technology LLC B228910
SB505124 (CAS 694433-59-5) is a selective small molecule inhibitor targeting the transforming growth factor-beta (TGF- ) type I receptors ALK4 ALK5 and ALK7 It acts as a reversible ATP-competitive inhibitor exhibiting IC50 values of 129 11 nM for ALK4 and 47 5 nM for ALK5 SB505124 efficiently suppresses the in vitro kinase activity of these receptors toward the substrate Smad3 In cellular models including HepG2 C2C12 and Mv1Lu cells SB505124 reduces TGF- -induced Smad2 phosphorylation in a concentration-dependent manner Additionally it demonstrates low cytotoxicity in A498 renal epithelial cells at concentrations up to 100 M for 48 hours This compound enables investigation of TGF- receptor signaling pathways and their roles in cellular processes
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