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Cayman Chemical SBI-0640756 10mg
Supplier: Cayman Chemical 4032810 MG
An inhibitor of eIF4G1; inhibits the association of eIF4G1 with the eIF4F complex in UACC-903 cell lysates in an m7GTP-agarose pull-down assay at 0.75 µM; inhibits eIF4G1-dependent and -independent mRNA translation in reporter assays using rabbit reticulocyte lysates (IC50s = 3.83 and 4.59 µM, respectively); reduces the growth of 1205Lu, WM1346, A375, UACC-903, and WM3629 melanoma cells; decreases tumor incidence by 50% in an N-RasQ61K-expressing, Ink4a-/- murine melanoma model at 0.5 mg/kg; decreases tumor volume in an A375 mouse xenograft model when used in combination with PLX4720
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