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Apexbio Technology LLC SC 144 895158-95-9 5mg
Supplier: Apexbio Technology LLC A21735
SC144 (CAS 895158-95-9) is an orally active small-molecule inhibitor that targets the gp130 receptor a component of the IL-6 cytokine family signaling pathway In vitro SC144 exhibits inhibitory activity against NCI/ADR-RES and HEY ovarian cancer cell lines with IC50 values of 0 43 M and 0 88 M respectively SC144 induces a time- and dose-dependent increase in phosphorylation of gp130 at S782 in ovarian cancer models disrupting the Stat3 signaling cascade supported by extracellular gp130 ligands This disruption leads to enhanced apoptosis and cell cycle perturbation Additionally SC144 has been reported to directly bind and stabilize IL-24 in cancer cells SC144 is utilized in research investigating targeted therapies for ovarian and colon cancer particularly involving the gp130/Stat3 axis and related apoptotic mechanisms
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