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Apexbio Technology LLC SC-514 354812-17-2 10mg
Supplier: Apexbio Technology LLC B158510
SC-514 (CAS 354812-17-2) is a cell-permeable and selective inhibitor of I B kinase 2 (IKK-2) exhibiting an IC50 range of 3 12 M against recombinant human IKK-2 SC-514 acts in a reversible and ATP-competitive manner at the ATP-binding site of IKK-2 and also inhibits the activity of the native IKK complex While it is an ATP-competitive inhibitor at IKK-2 SC-514 displays non-competitive inhibition at the I B substrate site In cellular models SC-514 suppresses I B phosphorylation and degradation reduces nuclear translocation of NF- B subunit p65 and dose-dependently decreases the expression of NF- B-dependent genes such as IL-6 IL-8 and COX-2 It has been utilized in studies exploring inflammatory signaling and osteoclastogenesis
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