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Apexbio Technology LLC SC 560 188817-13-2 10mg
SDP

Supplier:  Apexbio Technology LLC B678610

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SC 560 (CAS 188817-13-2) is a selective inhibitor of cyclooxygenase-1 (COX-1) exhibiting an IC50 of 0 009 M for COX-1 and 6 3 M for COX-2 By preferentially blocking COX-1 activity SC 560 impedes the conversion of arachidonic acid to prostaglandins such as thromboxane and PGE2 In vitro studies demonstrate that SC 560 suppresses COX-1-derived prostaglandin generation in a concentration-dependent manner inhibits cellular proliferation and induces apoptosis In vivo administration results in complete inhibition of COX-1-mediated thromboxane B2 and PGE2 production and attenuation of tumor growth in ovarian epithelial cancer models SC 560 serves as a valuable tool for investigating COX-1 s roles in inflammation pain and tumorigenesis

Catalog No. 50-000-88812


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