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Medchemexpress LLC SC57666 | 158959-32-1 | 316.39 | 50 MG
SDP

Supplier:  Medchemexpress LLC HYU0012950MG

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SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. It demonstrates high selectivity for COX2 over COX1, achieving an IC50 of 3.2 ± 0.8 nM in CHO cells and exhibiting over 1000-fold selectivity. This orally active compound has shown effectiveness in the adjuvant-induced arthritis model, with an ED50 of 1.7 mpk, and does not induce gastric lesions in mice or intestinal damage in rats at high dosages.

  • Selective COX2 inhibitor with an IC50 of 26 nM
  • Exhibits high selectivity (over 1000-fold) for COX2 over COX1
  • Orally active with an ED50 of 1.7 mpk in adjuvant-induced arthritis model
  • Does not cause gastric lesions in mice at 600 mpk
  • Does not cause intestinal damage in rats at 200 mpk
  • Provided as a white to off-white solid
  • Purity of 98.94%

Catalog No. 50-004-48719


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