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Apexbio Technology LLC SCH772984 942183-80-4 50mg
Supplier: Apexbio Technology LLC A380550
SCH772984 (CAS 942183-80-4) is an ATP-competitive inhibitor targeting ERK1 and ERK2 kinases It demonstrates high inhibitory activity against these enzymes with reported IC50 values of 4 nmol/L for ERK1 and 1 nmol/L for ERK2 Although it shows characteristics typical of both type I and II kinase inhibitors selectivity screening against approximately 300 kinases identified significant inhibition in only a few additional kinases at concentrations exceeding 1 mol/L SCH772984 has been shown in vitro to inhibit proliferation of tumor cells harboring BRAF NRAS or KRAS mutations highlighting its applicability in research focused on ERK signaling
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