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Medchemexpress LLC Seco-DUBA | 1227961-59-2 | 98.1% | 526.97 | 1 MG
Supplier: Medchemexpress LLC 1MGHY132180A
Seco-DUBA is a duocarmycin (DUBA) prodrug that contains two hydroxyl groups, each capable of coupling to an antibody via a linker. It is primarily used in the synthesis of antibody-drug conjugates (ADCs). Research indicates that Seco-DUBA dose-dependently reduces cell viability, demonstrating potency and efficacy comparable to DUBA in SK-BR-3 cells. It also induces high sensitivity in SK-BR-3, SK-OV-3, and SW620 cell lines. In vivo studies suggest that Seco-DUBA is likely converted to DUBA almost instantaneously.
- Contains two hydroxyl groups for antibody coupling via a linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
- Dose-dependently reduces cell viability
- Potent and efficacious as DUBA in SK-BR-3 cells
- Causes high sensitivity in SK-BR-3, SK-OV-3, and SW620 cells
- Likely converts to DUBA almost instantaneously in vivo
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