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Medchemexpress LLC Seladelpar (Lysine dihydrate) | 928821-40-3 | 98.0% | 626.68 | 5 MG
Supplier: Medchemexpress LLC HY19522C5MG
Seladelpar Lysine dihydrate is the Lysine dihydrate salt form of Seladelpar. It is an orally active agonist for potent PPAR-δ, with an EC50 of 2 nM. It exhibits high selectivity over PPARα and PPARγ receptors, making it suitable for the study of primary biliary cholangitis. This compound has also demonstrated the ability to normalize hyperglycemia, hyperinsulinemia, glucose, serum lipids, and cholesterol levels, and to ameliorate nonalcoholic steatohepatitis in mouse models.
- Orally active agonist for potent PPAR-δ with an EC50 of 2 nM.
- High selectivity over PPARα (>750-fold) and PPARγ (>2500-fold).
- Useful for studying primary biliary cholangitis.
- Normalizes hyperglycemia, hyperinsulinemia, glucose, serum lipids, and cholesterol levels.
- Ameliorates nonalcoholic steatohepatitis in mouse models.
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